Assumung you don't use these tricks anywhere, why not this (appropriately executed, using `sed -i` and maybe `find -exec ...`, which was not part of your question, was it?)

    $ sed 's/eval(gzuncompress(base64_decode(.*)));//' << EOF                     
    > <?php eval(gzuncompress(base64_decode('eF5Tcffxd3L0CY5WjzcyNDGGMV4+1dSwqSqzU0LQGAJCPCMM=')));eval(gzuncompress(base64_decode('eF5LK81LLsnMzKx+JjNW0rgUAqDUUxQ=='))); eval(gzuncompress(base64_decode('eF6VlMmy/3sMxOez/iJOojHFT0Ig/8jlTymmN/I=')));?>
    > EOF
    <?php  ?>

...you can afterwards deal with the empty `<?php  ?>`s (which don't hurt much, do they?).

**Edit** removed line breaks to make sure it fits to the situation described.

**Edit2** You'd be better off just replacing everything with a (*known good*) backup, probably, if you've got one.