On Linux Mint 21, after suspending and waking up, I cannot click on the Linux desktop menu or the taskbar or on chosen tabs in one of the Firefox windows or any open window like one of my open shells. I remember that this came up after putting the laptop on a docking station, but it could also have been triggered just from suspending and waking it up.
A short research hints at a kernel problem, see can't click buttons or other control in cinnamon desktop from 2014.
The "Have you tried turning it off and on again" voice whispers on a low level since there should be a better way than to lose all of the open sessions. How to get the clicks back without a restart?