Is it safe to remove /usr/lib32, /usr/libx32 directories and their links on /lib32, libx32, on 64bit only (no multiarch enabled) Debian Linux 10? They are empty.
Since this new file system hierarchy is used, I'm considering removing them to reduce clutter in /.


Yes, if they are empty, it’s safe to remove them. If you actually install packages which ship them (e.g. libc6-x32) and remove them, the directories are removed; so removing them manually in your case is fine.

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