Most instructions that I find online about adding or replacing kernel modules in Ubuntu only mention modprobe and rmmod. However, according my experience with e1000e, the modification is reverted after reboot unless I do update-initramfs -u afterwards. The man page of update-initramfs does not mention modules.
So, is it always necessary to run update-initramfs -u after replacing kernel modules if I want to have the modified kernel after reboot?