bash-4.2$ cat map.htm
<map name="world">
<area shape="rect" coords="0%,0%,32%,32%" >
<area shape="rect" coords="8%,40%,50%,80%" >
<area shape="rect" coords="56%,4%,84%,18%" >
<area shape="rect" coords="74%,20%,90%,40%" >
<area shape="rect" coords="70%,42%,96%,62%" >
<area shape="rect" coords="0%,74%,70%,95%" >
</map>
bash-4.2$ perl -pe '$w=640;$h=480;s!(\d+)%,(\d+)%,(\d+)%,(\d+)%!($1*$w/100).",".($2*$h/100).",".($3*$w/100).",".($4*$h/100)!ge' map.htm
<map name="world">
<area shape="rect" coords="0,0,204.8,153.6" >
<area shape="rect" coords="51.2,192,320,384" >
<area shape="rect" coords="358.4,19.2,537.6,86.4" >
<area shape="rect" coords="473.6,96,576,192" >
<area shape="rect" coords="448,201.6,614.4,297.6" >
<area shape="rect" coords="0,355.2,448,456" >
</map>
Of course this will fail in certain circumstances, because regular expressions are not the way to parse HTML, as concluded on SO. But solving with a dedicated HTML parser would not be a one-liner anymore.
But if you are sure there will be no conflicts with coordinate pair-looking plain text, you can even reduce it to this:
perl -pe '$w=640;$h=480;s!(\d+)%,(\d+)%!int($1*$w/100).",".int($2*$h/100)!ge' map.htm