Fedora has a Firewall Configuration interface:
Does this use
iptables underneath to enforce the rules?
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It pretty much has to, unless they've done a whole lot of reinventing the wheel in order to talk to the kernel's netfilter interface directly, which would mean a great deal of hassle for absolutely no benefit -- there's literally nothing that said interface can do that iptables can't tell it to.
If you want to be sure, go to a root console and type
You should see a list of active filter rules.