I have a Leap 42.1 ISO which I have imaged to a USB drive using USBImage on Windows 10. When I tried to boot from USB the first time I got the following message:
Trust openSUSE Certificate Do you agree to use the built-in openSUSE certificate to verify boot loaders and kernels? No Yes
After I selected Yes the machine appeared to freeze. I left it for a while then came back. Upon returning I found the computer had booted to Windows 10. I tried to boot via USB again, but now saw only a small grey cursor in the top left-hand corner of the screen for a minute or so, before being booted back to Windows 10.
The same openSUSE ISO installs fine on a VMWare Player VM on the same computer, which is an HP 165sa.