This solution works fine for two strings,but for three or more substitutions? I have tried

:%s:one:two:e | s:three:four:e | s:five:six:e

But the third line on this example remain the same

one
two
three
five
up vote 2 down vote accepted

You just forgot to place a % before your s command:

:%s:one:two:e | %s:three:four:e | %s:five:six:e

The % makes vim to search your whole text instead of just the current line.

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