It's probably not bad if they're "Bad", when you run on the AC power. When running on battery, the "Good/Bad" settings may or may not help. You can toggle them and observe the effects, but should you toggle them if you want to achieve the highest power-saving? I agree with mavit's answer that the powertop is primarily a diagnostic tool. There are other tools for turning on the power-saving mode.
An Ubuntu guy run exhaustive tests on two laptops and found, that generally it helps switching to the "Good" (low-power) mode, but not always. You can read his answer on askubuntu with the summary results linked from there.
After playing with powertop, I was looking for an automated solution. I use the laptop-mode-tools
package to automatically turn on power-saving features when the computer is working on batteries; enable the Kernel Laptop Mode, for example. I run sudo pm-powersave true
from the pm-utils
package to make my Thinkpad x200s consume minimum power, when I'm travelling. I installed the cpufrequtils
package to tweak the CPU frequency governor according to my immediate needs. I observed how the tunables look like when the automated tools configured the system.
Running on AC power after reboot:

Running on AC power after executing sudo pm-powersave true
:

Running on battery after executing sudo pm-powersave true
:

You see that most of the "Good" are probably really good to turn on, because the utilities turned them on too :-) I can say that the effect is very noticeable and it means for me going from 4 to 6 hous of the battery life, when I'm coding while travelling, for example.
UPDATE: If you want to turn all tunable flags to "Good" in some startup script, you can use the --auto-tune
parameter. Together with the pm-utils mentioned above it would be:
sudo pm-powersave true
sudo powertop --auto-tune
UPDATE II: Nowadays I do not use laptop-mode-tools
and pm-utils
any more. I use TLP from the latest Ubuntu distribution. It includes a daemon to take care of optimising the power consumption, when running on AC or in the battery mode. I still use PowerTOP as a diagnostic tool to check, that the system is configured correctly, when in doubt :-)