I get this
gpg: WARNING: The GNOME keyring manager hijacked the GnuPG agent. gpg: WARNING: GnuPG will not work proberly - please configure that tool to not interfere with the GnuPG system!
when I use gnupg-agent with mutt. But the warning doesn't give me clue how to resolve the issue, nor could I find the info from GNOME documentation.