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Memcached Issue connection lost in between Centos

I have a application server on with I m running load balance with nginx.. my memcached is getting crashed in between. below is my memcache.conf file. # memcached.conf port=11211 pidpath=/apps/home/...
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What is the difference between using varnish and caching content in memcached?

Do we need to deploy varnish if our Web application is using memcached or do we need memcached if we are using varnish to cache web contents. Can someone recommend some scenarios where should we use ...