That's the inode number for the pipe or socket in question.
A pipe is a unidirectional channel, with a write end and a read end. In your example, it looks like FD 5 and FD 6 are talking to each other, since the inode numbers are the same. (Maybe not, though. See below.)
More common than seeing a program talking to itself over a pipe is a pair of separate programs talking to each other, typically because you set up a pipe between them with a shell:
shell-1$ ls -lR / | less
Then in another terminal window:
shell-2$ ...find the ls and less PIDs with ps; say 4242 and 4243 for this example...
shell-2$ ls -l /proc/4242/fd | grep pipe
l-wx------ 1 user user 64 Mar 24 12:18 1 -> pipe:
shell-2$ ls -l /proc/4243/fd | grep pipe
l-wx------ 1 user user 64 Mar 24 12:18 0 -> pipe:
This says that PID 4242's standard output (FD 1, by convention) is connected to a pipe with inode number 222536390, and that PID 4243's standard input (FD 0) is connected to the same pipe.
All of which is a long way of saying that
ls's output is being sent to
Getting back to your example, FD 1 and FD 2 are almost certainly not talking to each other. Most likely this is the result of tying stdout (FD 1) and stderr (FD 2) together, so they both go to the same destination. You can do that with a Bourne shell like this:
$ some-program 2>&1 | some-other-program
So, if you poked around in
/proc/$PID_OF_SOME_OTHER_PROGRAM/fd, you'd find a third FD attached to a pipe with the same inode number as is attached to FDs 1 and 2 for the
some-program instance. This may also be what's happening with FDs 5 and 6 in your example, but I have no ready theory how these two FDs got tied together. You'd have to know what the program is doing internally to figure that out.